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What Is CBD (Cannabidiol)?

Cannabidiol, also known as CBD, is a cannabis compound found in hemp and sativa cannabis strains. Not to be confused with its psychoactive cousin component Tetrahydrocannabinol (THC), CBD offers significant medical benefits to users without any negative side effects. It’s important to note that though THC is responsible for the “high” feelings associated with ingestion of cannabis, CBD does not affect your body in this way. CBD-infused products will not get you high.

What is the endocannabinoid system?

Your body is home to the endocannabinoid system; a complex network of cannabinoid receptors and connected molecules. It’s responsible for helping regulate a huge variety of bodily functions, such as memory, sleep, motivation and reward, immune function, temperature, and appetite. The system contains two main types of receptor: CB1 and CB2. The differences between CBD (a non-psychoactive compound) and THC (a psychoactive compound) can be identified by studying the way each compound reacts with these receptors. CB1 receptors mainly influence the release and production of transmitters, while CB2 receptors are involved in maintaining the effectiveness of your immune system. THC interacts with these receptors by overwhelming the endocannabinoid system and bonding with the synapses, throwing it off balance and causing a psychoactive response linked with pleasure, memory, concentration and pain tolerance.

How does CBD interact with the endocannabinoid system?

Unlike THC, CBD does not bond with the CB1 receptors. Instead, it stimulates activity in both the CB1 and CB2 receptors without binding to them. Additionally, when CBD is introduced into the endocannabinoid system it increases the release of 2-AG. This is a naturally occuring endocannabinoid which is produced to enhance the overall effect of the endocannabinoid system on the body. In high concentrations, CBD can even activate the 5-HT14 serotonin receptor, which is responsible for producing anti-depressant effects. It also influences appetite, anxiety, sleep, pain perception, addiction mechanisms, and nausea.

Where does CBD come from?

Cannabidiol molecules are found in industrial hemp, as well as cannabis plants. Because industrial hemp has a low THC concentration, SmartCBD takes extra caution to preserve the raw nature of the hemp plant in order to extract from it the highest quality CBD. If you’re looking to purchase a CBD-infused product, SmartCBD’s extensive range offers a high-quality, natural alternative to wellbeing and health. Visit our products page to buy from the UK’s leading supplier of 100% organic, all-natural CBD products.

A Smart Vision

Your journey to a better quality of life starts with our products and the potential health benefits they can bring.

Our holistic understanding of the production process means we fine tune each individual step: from choosing the right soil for the CBD crops to the smartest, most effective extraction methods. We focus on end-to-end quality assurance and optimal purity.

As an environmentally conscious company, we refuse to compromise on either quality or sustainable processing. We nurture the very best European-certified hemp seeds into 100% organic plants – this results in quality assured cannabinoid strains of the highest calibre. Our 100% recyclable cardboard packaging comes with a free post bag, plus a discount for customers who post their plastic containers back to us.

Frequently Asked Questions

Answered by SmartCBD experts

Is CBD legal in the UK?

CBD is legal in the UK and is commonly sold as a food supplement. All SmartCBD products are produced using hemp and are completely legal for consumption and sale in the UK.

Will I fail a drug test?

Drug tests are typically geared towards identifying THC and not CBD or other Cannabinoids. Some CBD oils may contain trace amounts of THC and this may register on a drug test. Take a look at our range of CBD oils’s and balms with zero THC.

Will CBD get me 'high'?

CBD oil will not get you ‘high’ in the traditional sense of smoking or ingesting marijuana. That is because marijuana contains high levels of Tetrahydrocannabinol (THC). THC is the drug that causes people to feel the “hazy” or “stoned” effects typically associated with marijuana use.

Is SmartCBD made synthetically?

No. All of our products are made 100% organically with natural and complex Cannibinoids, the way nature intended.

Does CBD oil help with pain?

Promising studies on the effects of CBD oil’s use for pain management have been carried out. CBD users say that Cannibinoids can offer a natural alternative for people who have chronic pain.

Will CBD make me drowsy?

A lot of our customers, when writing reviews about our CBD products, talk about how “relaxed” they feel as opposed to drowsy.

Research & Studies

CBD & Other Cannibinoids

Please note: The below studies involve CBD and other cannabinoids. We have provided this list of research solely for the purpose of educating those who would like to learn more about the potential wellness and health benefits of CBD. SmartCBD products are not yet medically proven to diagnose, prevent, treat or cure any disease.

CBD and Inflammation

2012 – Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A(2A) receptor.
2012 – Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview
2010 – Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation

CBD and Anxiety

2012 – Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
2012 – On disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
2011 – The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives
2011 – Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress
2011 – Cannabidiol potentiates Delta(9)-tetrahydrocannabinol (THC) behavioral effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
2011 – Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients
2011 – Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
2010 – Therapeutical use of the cannabinoids in pyschiatry
2010 – A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice

CBD and Depression

2010 – Antidepressant-like effect of Delta (9)-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa

CBD and Pain

2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors
2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes

CBD and Arthritis

2000 – The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

CBD and Memory

2010 – Key ingredient staves off marijuana memory loss
2010 – Key ingredient dilutes marijuana’s effect on memory
2010 – Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

CBD and Seizures

2012 – Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
2010 – Anticonvulsant effects of GWP42006 in vitro and in vivo in rats
2010 – Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

CBD and Alzheimer’s Disease & Dementia

2012 – The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
2012 – Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
2011 – Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease
2011 – Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
2011 – Prospects for cannabinoid therapies in basal ganglia disorders
2011 – Phytocannabinoids as novel therapeutic agents in CNS disorders

CBD and Breast Cancer

2011 – Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
2011 – Cannabidiol induces programmed cell death in breast cancer cells by coordinating the crosstalk between apoptosis and autophagy

CBD and Brain Damage

2011 – Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
2010 – Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania
2010 – Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
2010 – Opposite Effects of Delta9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
2010 – Disposition of Cannabichromene, Cannabidiol, and Delta9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry
2010 – Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture
2010 – The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
2010 – Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

CBD and Lung Cancer

2010 – Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells.

CBD and Cancer Cells

2012 – Cannabidiol Inhibits Angiogenesis by Multiple Mechanisms
2012 – Poly-e-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development characterization and in vitro evaluation of their antitumoral efficacy
2012 – Cannabidiol-induced apoptosis in murine microglial cells through lipid raft
2011 – Phytocannabinoids for use in the treatment of cancer – Patent GB2478595(A) 
2011 – Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes
2010 – Antitumorigenic Effects of Cannabinoids beyond Apoptosis
2010 – Anti-tumoural effects of cannabinoid combinations – Patent TW201002315 (A)
2010 – Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases
2010 – Cannabidiol Enhances the Inhibitory Effects of Delta9 – Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
2010 – Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity
2010 – Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of efficacy, safety, and tolerability of THC

CBD and Brain Cancer

2010 – Science: Cannabidiol enhances the anti-cancer effects of THC on human brain cancer cells.

CBD and Cardiac Arrythmias

2010 – Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.
2010 – Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors

CBD and Diabetes

2011 – The potential for clinical use of cannabinoids in treatment of cardiovascular diseases
2010 – Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
2010 – Lab Notes: Pot Has Benefits for Diabetic Hearts

CBD and Colon Cancer

2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors
2012 – Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
2011 – Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes

CBD and Cholesterol

2011 – The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells

CBD and Appetite

2012 – Cannabinol and cannabidiol exert opposing effects on rat feeding patterns
2010 – Cannabidiol Attenuates the Appetitive Effects of Delta9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis

CBD and Nausea

2011 – Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
2011 – Cannabidiol, a Non-Psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus
2011 – Regulation of nausea and vomiting by cannabinoids
2010 – Regulation of nausea and vomiting by cannabinoids

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